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These results show siRNAs rapidly access all layers in the retina after either intravitreous or periocular injection and they are detectable for several days after injection. In all, 5 l containing 25 g of BrdU labeled Sirna 027 was injected to the periocular space of mice and, at 6, 12, 24, or 48 h (h) or Five days after injection, mice were euthanized and ocular frozen sections were immunohistochemically stained for BrdU. At 6 h after injection, staining was
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